Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 16/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | BLK | P51451 | 1/20 | 0.56 |
| ▸ | BMX | P51813 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430952 | 1.00 | KDM4E (0.60) | KDM4EEGFRERBB2ERBB4FYN | |
| SCHEMBL8434635 | 1.00 | KDM4E (0.60) | KDM4EEGFRERBB2ERBB4FYN | |
| SCHEMBL8432791 | 0.88 | EGFR (0.59) | EGFRERBB2ERBB4 | |
| SCHEMBL8432793 | 0.88 | EGFR (0.59) | EGFRERBB2ERBB4 | |
| SCHEMBL7122834 | 0.84 | EGFR (0.70) | KDM4EEGFRERBB2ERBB4FYN | |
| SCHEMBL7161985 | 0.81 | EGFR (0.64) | KDM4EEGFRERBB2ERBB4FYN | |
| SCHEMBL6273052 | 0.80 | EGFR (0.70) | KDM4EEGFRERBB2ERBB4FYN | |
| SCHEMBL2990711 | 0.79 | EGFR (0.72) | KDM4EEGFRERBB2ERBB4FYN | |
| SCHEMBL8430897 | 0.78 | BRAF (0.48) | EGFRBTK | |
| SCHEMBL27522925 | 0.76 | EGFR (0.70) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929080-A | ADMINISTERING PHENYLAMINOQUINAZOLINE DERIVATIVE | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | claimed |
| US-5760041-A | 4-aminoquinazoline EGFR Inhibitors | AMERICAN CYANAMID COMPANY (US) | 1998-06-02 | — | — | US | claimed |
| US-5929080-A | ADMINISTERING PHENYLAMINOQUINAZOLINE DERIVATIVE | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| US-5760041-A | 4-aminoquinazoline EGFR Inhibitors | AMERICAN CYANAMID COMPANY (US) | 1998-06-02 | — | — | US | disclosed |