SCHEMBL8433725

SCHEMBL8433725

CC(CNCc1ccc(OCc2ccccc2F)cc1)C(N)=O

nearest known ligand 0.72

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 2/20 0.72
SCN3A Q9NY46 4/20 0.69
MAOB P27338 7/20 0.55
PARP15 Q460N3 2/20 0.55
PARP10 Q53GL7 2/20 0.55
PARP14 Q460N5 1/20 0.55
KCNH2 Q12809 1/20 0.47
MAOA P21397 1/20 0.47
PTPN1 P18031 1/20 0.47
BCHE P06276 1/20 0.46
LPAR1 Q92633 1/20 0.46
LPAR5 Q9H1C0 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL963787 0.85 SCN9A (0.85) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL963773 0.84 SCN9A (0.79) SCN9ASCN3AMAOBPARP15PARP10
Ralfinamide SCHEMBL962699 0.84 SCN9A (1.00) SCN9ASCN3AMAOBPARP15PARP10
Ralfinamide SCHEMBL29379049 0.84 SCN9A (1.00) SCN9ASCN3AMAOBPARP15PARP10
Ralfinamide SCHEMBL67328 0.84 SCN9A (1.00) SCN9ASCN3AMAOBPARP15PARP10
Ralfinamide SCHEMBL67329 0.84 SCN9A (1.00) SCN9ASCN3AMAOBPARP15PARP10
SCHEMBL8432752 0.83 MAOB (0.56) SCN9AMAOBPARP10MAOABCHE
SCHEMBL963500 0.83 SCN9A (0.78) SCN9ASCN3AMAOBPARP15PARP10
Ralfinamide SCHEMBL1697253 0.83 SCN9A (0.98) SCN9ASCN3AMAOBPARP15PARP10
Ralfinamide SCHEMBL1697252 0.83 SCN9A (0.98) SCN9ASCN3AMAOBPARP15PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5945454-A 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives PHARMACIA & UPJOHN, S.P.A. (IT) 1999-08-31 US claimed
US-5945454-A 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives PHARMACIA & UPJOHN, S.P.A. (IT) 1999-08-31 US disclosed