Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.52 |
| ▸ | EDNRB | P24530 | 7/20 | 0.39 |
| ▸ | BRS3 | P32247 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501757 | 0.92 | EDNRA (0.55) | EDNRAEDNRBBRS3 | |
| SCHEMBL7495951 | 0.89 | EDNRA (0.46) | EDNRAEDNRBBRS3KDM4EALDH1A1 | |
| SCHEMBL6579920 | 0.89 | EDNRA (0.46) | EDNRAEDNRBBRS3KDM4EALDH1A1 | |
| SCHEMBL7501755 | 0.88 | EDNRA (0.44) | EDNRAEDNRBBRS3KDM4EALDH1A1 | |
| SCHEMBL9093216 | 0.88 | EDNRA (0.46) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL8435187 | 0.87 | EDNRA (0.44) | EDNRAEDNRBBRS3KDM4EALDH1A1 | |
| SCHEMBL6580198 | 0.87 | EDNRA (0.44) | EDNRAEDNRBKDM4EALDH1A1HPGD | |
| SCHEMBL7494883 | 0.86 | EDNRA (0.46) | EDNRAEDNRBBRS3KDM4EALDH1A1 | |
| SCHEMBL6582508 | 0.86 | EDNRA (0.43) | EDNRAEDNRBALDH1A1 | |
| SCHEMBL6582430 | 0.85 | EDNRA (0.43) | EDNRAEDNRBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |