Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 6/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.46 |
| ▸ | TPSAB1 | Q15661 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436310 | 0.91 | PRSS1 (0.47) | PRSS1PRSS2PRSS3TPSAB1KMT2A | |
| SCHEMBL8433744 | 0.89 | PRSS1 (0.49) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8434774 | 0.87 | PRSS1 (0.47) | PRSS1PRSS2PRSS3TPSAB1RAB9A | |
| SCHEMBL8433320 | 0.85 | PRSS1 (0.42) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8436495 | 0.84 | HDAC6 (0.42) | ALDH1A1CTSLCTSKATM | |
| SCHEMBL8436757 | 0.84 | PRSS1 (0.54) | PRSS1PRSS2PRSS3TPSAB1RAB9A | |
| SCHEMBL8433890 | 0.83 | ATM (0.43) | PRSS1PRSS2PRSS3TPSAB1KMT2A | |
| SCHEMBL8433178 | 0.83 | PRSS1 (0.42) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8435692 | 0.82 | ATM (0.41) | PRSS1PRSS2PRSS3TPSAB1ATM | |
| SCHEMBL8435266 | 0.82 | PRSS1 (0.41) | PRSS1PRSS2PRSS3TPSAB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |