Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.43 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20848126 | 1.00 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 | |
| SCHEMBL8564168 | 1.00 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 | |
| SCHEMBL19083304 | 0.91 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 | |
| SCHEMBL19063785 | 0.91 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 | |
| SCHEMBL19098262 | 0.91 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 | |
| SCHEMBL19123095 | 0.91 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 | |
| SCHEMBL7804232 | 0.91 | KMT2A (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 | |
| SCHEMBL21684765 | 0.90 | KMT2A (0.51) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 | |
| SCHEMBL20722866 | 0.90 | KMT2A (0.51) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 | |
| SCHEMBL376613 | 0.90 | KMT2A (0.51) | KMT2AL3MBTL1NPFFR1NPFFR2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113631557-B | JAK kinase inhibitor, preparation method thereof and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-109535164-B | JAK kinase inhibitor, preparation method thereof and application thereof in medical field | 上海华汇拓医药科技有限公司 | 2022-01-18 | — | — | CN | disclosed |
| CN-113631557-A | JAK kinase inhibitor, preparation method thereof and application thereof in medical field | 上海华汇拓医药科技有限公司 | 2021-11-09 | — | — | CN | disclosed |
| WO-2019057103-A1 | JAK INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION IN THE FIELD OF MEDICINE | 上海华汇拓医药科技有限公司 | 2019-03-28 | — | — | WO | disclosed |
| US-5859026-A | ADMINISTERING AS AN ANTIBACTERIAL AGENT | HOKURIKU SEIYAKU CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| US-5837868-A | REACTION OF DIHYDROXY OLEFINS IN A MULTISTAGE PROCESS ARYL METHYLAMINE TO FORM PYRROLIDINE INTERMEDIATE | ABBOTT LABORATORIES (US) | 1998-11-17 | — | — | US | disclosed |
| US-5703244-A | CYCLIZATION OF DIHYDROXY OLEFINS WITH TARTRATE ESTER IN PRESENCE OF TITANIUM ISOPROPOXIDE AND TERT-BUTYL HYDROPEROXIDE | ABBOTT LABORATORIES (US) | 1997-12-30 | — | — | US | disclosed |