Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 13/20 | 0.75 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.75 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.75 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.75 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.75 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.75 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1071844 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL1931918 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL19697632 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL8659794 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL24408031 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL24999988 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL18827757 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL24001462 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL16361266 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 | |
| SCHEMBL16361423 | 1.00 | GPBAR1 (0.75) | GPBAR1NR1H4MEN1KMT2AABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869319-A | FACULTATIVE ANAEROBE WHICH PRODUCES 7-BETA-HYDROXY BILE ACIDS FROM SUBSTRATES HAVING 7-ALPHA-HYDROXY OR 7-KETO GROUPS FOR SAFE, SIMPLE, EFFICIENT COMMERCIAL PRODUCTION | TOKYO TANABE COMPANY LIMITED (JP) | 1999-02-09 | — | — | US | claimed |
| EP-0872546-A1 | NOVEL BILE ACID-CONVERTING MICROORGANISM | TOKYO TANABE COMPANY LIMITED (JP) | 1998-10-21 | — | — | EP | claimed |
| EP-0583566-B1 | Process for the preparation of glycine-conjugated bile acids | ERREGIERRE IND CHIM (IT) | 1998-09-23 | — | — | EP | claimed |