Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.34 |
| ▸ | HTR3A | P46098 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL843605 | 1.00 | CHRNA7 (0.58) | CHRNA7CHRM4HTR3AUSP30HTR3E | |
| SCHEMBL843511 | 0.93 | CHRNA7 (0.60) | CHRNA7CHRM4HTR3AUSP30HTR3E | |
| SCHEMBL843510 | 0.93 | CHRNA7 (0.60) | CHRNA7CHRM4HTR3AUSP30HTR3E | |
| SCHEMBL843854 | 0.92 | CHRNA7 (0.59) | CHRNA7CHRM4HTR3AUSP30 | |
| SCHEMBL844262 | 0.92 | CHRNA7 (0.59) | CHRNA7CHRM4HTR3AUSP30 | |
| SCHEMBL843989 | 0.90 | CHRNA7 (0.59) | CHRNA7CHRM4HTR3AADRA1A | |
| SCHEMBL844452 | 0.90 | CHRNA7 (0.57) | CHRNA7CHRM4HTR3AUSP30 | |
| SCHEMBL842538 | 0.90 | CHRNA7 (0.57) | CHRNA7CHRM4HTR3A | |
| SCHEMBL844451 | 0.90 | CHRNA7 (0.57) | CHRNA7CHRM4HTR3AUSP30 | |
| SCHEMBL842539 | 0.90 | CHRNA7 (0.57) | CHRNA7CHRM4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432707-B1 | AZABICYCLIC-SUBSTITUTED FUSED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN CO LLC (US) | 2012-03-28 | — | — | EP | claimed |
| EP-1432707-B1 | AZABICYCLIC-SUBSTITUTED FUSED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN CO LLC (US) | 2012-03-28 | — | — | EP | disclosed |