Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
| ▸ | MME | P08473 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2306121 | 0.98 | CYP2C19 (0.52) | CYP2C19TBXAS1MMEUSP2ALDH1A1 | |
| SCHEMBL517418 | 0.88 | — | — | |
| SCHEMBL2005168 | 0.80 | CYP2C19 (0.54) | CYP2C19TBXAS1MMEUSP2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10824186 | 0.78 | CYP2C19 (0.52) | CYP2C19TBXAS1MMEUSP2ALDH1A1 | |
| SCHEMBL7154813 | 0.78 | CYP2C19 (0.52) | CYP2C19TBXAS1MMEUSP2ALDH1A1 | |
| SCHEMBL15059607 | 0.77 | CYP2C19 (0.35) | CYP2C19 | |
| SCHEMBL11634222 | 0.77 | CYP2C19 (0.50) | CYP2C19TBXAS1MMEALDH1A1 | |
| Dimethyl Sulfoxide SCHEMBL28235048 | 0.77 | CYP2C19 (0.32) | CYP2C19 | |
| SCHEMBL9342816 | 0.75 | CYP2C19 (0.65) | CYP2C19TBXAS1MMEUSP2ALDH1A1 | |
| SCHEMBL125690 | 0.75 | CYP2C19 (0.65) | CYP2C19TBXAS1MMEUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908937-A | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives | SCHERING-PLOUGH LTD. (CH) | 1999-06-01 | — | — | US | disclosed |
| US-5567844-A | Process for preparing 1-phenyl-2-amino-3-fluoro-1-propanols | ZAMBON S.P.A. (IT) | 1996-10-22 | — | — | US | disclosed |
| EP-0130633-B1 | Process for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives | ZAMBON SPA (IT) | 1996-10-09 | — | — | EP | disclosed |
| EP-0678506-A2 | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives | ZAMBON GROUP S.p.A. (IT) | 1995-10-25 | — | — | EP | disclosed |
| EP-0677511-A2 | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives | ZAMBON GROUP S.p.A. (IT) | 1995-10-18 | — | — | EP | disclosed |
| US-5332835-A | Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process | ZAMBON S.P.A. (IT) | 1994-07-26 | — | — | US | disclosed |
| US-5243056-A | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives | ZAMBON S.P.A. (IT) | 1993-09-07 | — | — | US | disclosed |
| US-5153328-A | 2 Hydrocarbyl-4 substituted methyl 5 (4 substituted phenyl)-oxazolines | ZAMBON S.P.A. (IT) | 1992-10-06 | — | — | US | disclosed |
| US-5105009-A | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives | ZAMBON S.P.A. (IT) | 1992-04-14 | — | — | US | disclosed |
| US-4743700-A | Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds | ZAMBON S.P.A. (IT) | 1988-05-10 | — | — | US | disclosed |
| EP-0130633-A2 | Process for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives | ZAMBON GROUP S.p.A. (IT) | 1985-01-09 | — | — | EP | disclosed |