Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8435658 | 0.90 | ATM (0.47) | ATMTRPM8TACR1CTRB1 | |
| SCHEMBL8433075 | 0.88 | ATM (0.45) | ATMTRPM8ALDH1A1ALOX15CTRB1 | |
| SCHEMBL8436495 | 0.86 | HDAC6 (0.42) | ATMTRPM8ALDH1A1ALOX15 | |
| SCHEMBL8432908 | 0.86 | TACR1 (0.46) | ATMTRPM8TACR1ALDH1A1ALOX15 | |
| SCHEMBL8433744 | 0.86 | PRSS1 (0.49) | ATMTRPM8 | |
| SCHEMBL8433890 | 0.85 | ATM (0.43) | ATMTRPM8ALDH1A1ALOX15CTRB1 | |
| SCHEMBL8435692 | 0.84 | ATM (0.41) | ATMTRPM8CTRB1 | |
| SCHEMBL8433808 | 0.83 | ATM (0.41) | ATMTRPM8ALDH1A1ALOX15MEN1 | |
| SCHEMBL8433320 | 0.83 | PRSS1 (0.42) | ATMTRPM8 | |
| SCHEMBL8436757 | 0.81 | PRSS1 (0.54) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |