Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208567 | 0.79 | MAOB (0.48) | CA12CA9S1PR1MAOBHPGD | |
| SCHEMBL8439103 | 0.78 | GRM1 (0.43) | CA12CA9L3MBTL1MAOBLMNA | |
| SCHEMBL8441752 | 0.77 | VKORC1 (0.58) | CA12CA9L3MBTL1MAOBLMNA | |
| SCHEMBL8439032 | 0.74 | NPC1 (0.53) | CA12CA9L3MBTL1LMNAHPGD | |
| SCHEMBL9209186 | 0.73 | HIF1A (0.54) | CA12CA9MAOBLMNAHPGD | |
| SCHEMBL7615738 | 0.73 | MAOB (0.56) | CA12CA9L3MBTL1MAOBLMNA | |
| SCHEMBL7616879 | 0.72 | CA12 (0.61) | CA12CA9MAOBLMNAHPGD | |
| SCHEMBL9209466 | 0.72 | MAOB (0.60) | CA12CA9MAOBLMNAHPGD | |
| SCHEMBL11869295 | 0.72 | SERPINE1 (0.57) | CA12CA9MAOBLMNAHPGD | |
| SCHEMBL9201665 | 0.72 | MAOB (0.58) | CA12CA9MAOBLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985912-A | COUMARONE COMPOUNDS AS BACTERICIDES | PFIZER INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5624951-A | 4-hydroxy coumarin derivatives with antibacterial activity | PFIZER INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0658158-A1 | 4-HYDROXY COUMARIN DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | PFIZER INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005649-A1 | 4-HYDROXY COUMARIN DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | PFIZER INC. (US) | 1994-03-17 | — | — | WO | disclosed |