Bicarbonate

SCHEMBL8440459

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nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3A GSK3B IMPA1

The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	CA1	P00915	2/20	0.83

▸	CA2	P00918	1/20	0.83

▸	CA9	Q16790	1/20	0.83

▸	FFAR3	O14843	2/20	0.44

▸	ACHE	P22303	1/20	0.44

▸	LCK	P06239	1/20	0.44

▸	FYN	P06241	1/20	0.44

▸	CA4	P22748	1/20	0.40

▸	FAHD1	Q6P587	1/20	0.40

▸	TSHR	P16473	3/20	0.36

▸	LDHA	P00338	2/20	0.36

▸	EGLN1	Q9GZT9	2/20	0.36

▸	LMNA	P02545	2/20	0.36

▸	LDHB	P07195	1/20	0.36

▸	SRR	Q9GZT4	1/20	0.36

▸	TP53	P04637	1/20	0.36

▸	ALKBH5	Q6P6C2	1/20	0.36

▸	SUCNR1	Q9BXA5	1/20	0.36

▸	EGLN3	Q9H6Z9	1/20	0.36

▸	OR51E2	Q9H255	2/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Bicarbonate SCHEMBL7520782	1.00	CA1 (0.83)	CA1CA2CA9FFAR3ACHE
Bicarbonate SCHEMBL11166404	1.00	CA1 (0.83)	CA1CA2CA9FFAR3ACHE
Bicarbonate SCHEMBL9636303	1.00	CA1 (0.83)	CA1CA2CA9FFAR3ACHE
Bicarbonate SCHEMBL9395678	1.00	CA1 (0.83)	CA1CA2CA9FFAR3ACHE
Bicarbonate SCHEMBL11133737	1.00	CA1 (0.83)	CA1CA2CA9FFAR3ACHE
Bicarbonate SCHEMBL11619417	1.00	CA1 (0.83)	CA1CA2CA9FFAR3ACHE
Bicarbonate SCHEMBL9398103	1.00	CA1 (0.83)	CA1CA2CA9FFAR3ACHE
Bicarbonate SCHEMBL8859987	1.00	CA1 (0.83)	CA1CA2CA9FFAR3ACHE
Bicarbonate SCHEMBL2786367	0.93	—	—
Bicarbonate SCHEMBL614471	0.93	—	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5955057-A	SODIUM BICARBONATE, ORGANIC ACID, ALCOHOL	BIOTECH HOLDINGS LTD. (CA)	1999-09-21	—	—	US	claimed