Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 7/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978775 | 0.82 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL6654540 | 0.81 | MAPK13 (0.68) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL27497826 | 0.79 | MAPK13 (0.91) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL6658069 | 0.76 | MAPK13 (0.78) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL6654831 | 0.76 | MAPK13 (0.85) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL6655626 | 0.75 | MAPK13 (0.56) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL6653092 | 0.73 | MAPK13 (0.74) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL6652732 | 0.73 | MAPK13 (1.00) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL6655478 | 0.73 | MAPK13 (0.74) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL27497518 | 0.73 | MAPK13 (0.74) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966423-A1 | HYDROXYMETHYL DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE AS CARDIOVASCULAR AGENT | ZAMBON GROUP S.p.A. (IT) | 1999-12-29 | — | — | EP | disclosed |
| EP-0966424-A1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998038154-A1 | HYDROXYMETHYL DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE AS CARDIOVASCULAR AGENT | ZAMBON GROUP S.P.A. (IT) | 1998-09-03 | — | — | WO | disclosed |
| WO-1998032730-A1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-07-30 | — | — | WO | disclosed |