Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 12/20 | 0.59 |
| ▸ | PPARG | P37231 | 10/20 | 0.59 |
| ▸ | PPARA | Q07869 | 9/20 | 0.59 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659761 | 0.87 | PPARD (0.70) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL8443096 | 0.85 | PPARD (0.61) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL8439533 | 0.84 | PPARD (0.69) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6936087 | 0.83 | PPARD (0.71) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6936091 | 0.83 | PPARD (0.71) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6934158 | 0.82 | PPARD (0.66) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6931405 | 0.82 | PPARD (0.69) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL8443731 | 0.81 | PPARG (0.60) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6931450 | 0.81 | PPARG (0.61) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL7074267 | 0.81 | PPARA (0.61) | PPARDPPARGPPARANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | claimed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |