Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3662825 | 1.00 | MEN1 (0.51) | MEN1KMT2AKDM4CCHRNA7PSMB1 | |
| Bromide SCHEMBL31076183 | 1.00 | MEN1 (0.51) | MEN1KMT2AKDM4CCHRNA7PSMB1 | |
| Bromide SCHEMBL11354372 | 1.00 | MEN1 (0.51) | MEN1KMT2AKDM4CCHRNA7PSMB1 | |
| Bromide SCHEMBL11517500 | 0.99 | MEN1 (0.49) | MEN1KMT2AKDM4CCHRNA7PSMB1 | |
| Bromide SCHEMBL5214341 | 0.96 | MEN1 (0.49) | MEN1KMT2AKDM4CCHRNA7PSMB1 | |
| Iodide SCHEMBL7755123 | 0.93 | MEN1 (0.49) | MEN1KMT2AKDM4CCHRNA7PSMB1 | |
| Bromide SCHEMBL7324390 | 0.91 | KDM4C (0.47) | MEN1KMT2AKDM4CCHRNA7L3MBTL1 | |
| Iodide SCHEMBL28851041 | 0.88 | MEN1 (0.46) | MEN1KMT2AKDM4CCHRNA7PSMB1 | |
| Bromide SCHEMBL31076166 | 0.85 | MEN1 (0.42) | MEN1KMT2AKDM4CCHRNA7L3MBTL1 | |
| Bromide SCHEMBL23387051 | 0.83 | CHRNA7 (0.36) | MEN1KMT2AKDM4CCHRNA7PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675130-B1 | Process for the preparation of phosphonium salts | SHINETSU CHEMICAL CO (JP) | 1999-12-29 | — | — | EP | disclosed |
| US-5481040-A | REACTING A PHOSPHINE WITH A CHLORIDE IN THE PRESENCE OF AN ALKALI METAL SALT AND A SOLVENT | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0675130-A2 | Process for the preparation of phosphonium salts | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1995-10-04 | — | — | EP | disclosed |
| EP-0201823-B1 | NOVEL INTERMEDIATES FOR THE PRODUCTION OF PHARMACEUTICALS | LILLY INDUSTRIES LIMITED (GB) | 1990-12-05 | — | — | EP | disclosed |
| US-4963578-A | LEUKOTRIN ANTAGONISTS; ANTIALLERGENS | LILLY INDUSTRIES LIMITED (GB) | 1990-10-16 | — | — | US | disclosed |
| US-RE33300-E | LEUKOTRIENE ANTAGONISTS; ANTIALLERGENS | ELI LILLY AND COMPANY (US) | 1990-08-14 | — | — | US | disclosed |
| EP-0134111-B1 | ARALIPHATIC SULPHIDES,SULPHONES AND SULPHOXIDES AND THEIR PHARMACEUTICAL USE | Lilly Industries Limited (GB) | 1988-12-07 | — | — | EP | disclosed |
| US-4665189-A | LEUKOTRIENE ANTAGONISTS | LILLY INDUSTRIES LIMITED (GB) | 1987-05-12 | — | — | US | disclosed |
| EP-0201823-A2 | Novel intermediates for the production of pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1986-11-20 | — | — | EP | disclosed |
| EP-0134111-A1 | Araliphatic sulphides,sulphones and sulphoxides and their pharmaceutical use | Lilly Industries Limited (GB) | 1985-03-13 | — | — | EP | disclosed |