Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 11/20 | 0.65 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL843414 | 1.00 | CHRNA7 (0.65) | CHRNA7SMYD3HTR3EHTR3BHTR3A | |
| SCHEMBL843415 | 1.00 | CHRNA7 (0.65) | CHRNA7SMYD3HTR3EHTR3BHTR3A | |
| SCHEMBL842443 | 0.95 | CHRNA7 (0.58) | CHRNA7SMYD3HTR3EHTR3BHTR3A | |
| SCHEMBL5290539 | 0.83 | SMYD3 (0.58) | SMYD3HDAC6 | |
| SCHEMBL843748 | 0.82 | CHRNA7 (0.58) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6482341 | 0.81 | CHRNA7 (0.63) | CHRNA7SMYD3HTR3AKDM5AHDAC6 | |
| SCHEMBL6481419 | 0.81 | CHRNA7 (0.63) | CHRNA7SMYD3HTR3AKDM5AHDAC6 | |
| SCHEMBL6009148 | 0.81 | CHRNA7 (0.65) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6007434 | 0.81 | CHRNA7 (0.65) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6488622 | 0.80 | CHRNA7 (0.65) | CHRNA7SMYD3HTR3AKDM5AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432707-B1 | AZABICYCLIC-SUBSTITUTED FUSED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN CO LLC (US) | 2012-03-28 | — | — | EP | disclosed |