Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | IL2 | P60568 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20410843 | 0.91 | KDM4E (0.59) | KDM4EHRH3HTTLMNAMAPT | |
| SCHEMBL8491691 | 0.89 | HPGD (0.55) | KDM4EHRH3HTTLMNAMAPT | |
| SCHEMBL471881 | 0.87 | KDM4E (0.62) | KDM4EHRH3HTTLMNAMAPT | |
| SCHEMBL20410735 | 0.86 | KDM4E (0.54) | KDM4EHRH3HTTLMNAMAPT | |
| SCHEMBL8442835 | 0.85 | KDM4E (0.50) | KDM4EHRH3HTTLMNAMAPT | |
| SCHEMBL29689817 | 0.85 | KDM4E (0.53) | KDM4EHRH3HTTLMNAMAPT | |
| SCHEMBL20396188 | 0.85 | KDM4E (0.53) | KDM4EHRH3HTTLMNAMAPT | |
| SCHEMBL20410829 | 0.84 | KDM4E (0.51) | KDM4EHRH3HTTLMNAMAPT | |
| SCHEMBL20410729 | 0.82 | KDM4E (0.53) | KDM4EHRH3HTTLMNAMAPT | |
| SCHEMBL8439322 | 0.81 | KDM4E (0.46) | KDM4EHRH3HTTLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968985-A | INHIBITORS OF SODIUM ION/HYDROGEN ION EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0773927-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996004241-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |