⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8506805 | 0.78 | — | — | |
| SCHEMBL301522 | 0.72 | — | — | |
| SCHEMBL14645381 | 0.69 | — | — | |
| SCHEMBL6692233 | 0.65 | — | — | |
| SCHEMBL20556429 | 0.62 | — | — | |
| SCHEMBL6698611 | 0.61 | — | — | |
| SCHEMBL21634061 | 0.61 | — | — | |
| SCHEMBL653824 | 0.60 | — | — | |
| SCHEMBL3939068 | 0.60 | — | — | |
| SCHEMBL21634047 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008411-A | THE ANTIBODIES AND ENZYME CONJUGATES ARE PROVIDED IN COMBINATION IN KITS TO BE USED FOR THE RAPID AND ACCURATE DETERMINATION OF NORTRIPTYLINE IN SERUM AND OTHER BODILY FLUIDS; A TRICYCLIC ANTIDEPRESSANT | DADE BEHRING MARBURG GMBH (DE) | 1999-12-28 | — | — | US | disclosed |
| EP-0177344-B1 | SERUM PRETREATMENT FOR TRICYCLIC ANTIDEPRESSANT DRUG ASSAYS AND KIT THEREFOR | SYNTEX (U.S.A.) INC. (US) | 1992-04-08 | — | — | EP | disclosed |
| EP-0167256-B1 | NORTRIPTYLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, CONJUGATES THEREOF TO ANTIGENIC PROTEINS AND ENZYMES, ANTIBODIES THERETO, AND RELATED ASSAY METHODS | SYNTEX (U.S.A.) INC. (US) | 1991-08-21 | — | — | EP | disclosed |
| US-4795822-A | ANTIDEPRESSANT | SYNTEX (U.S.A.) INC. (US) | 1989-01-03 | — | — | US | disclosed |
| EP-0177344-A2 | Serum pretreatment for tricyclic antidepressant drug assays and kit therefor | SYNTEX (U.S.A.) INC. (US) | 1986-04-09 | — | — | EP | disclosed |
| EP-0167256-A1 | Nortriptyline derivatives, processes for their preparation, conjugates thereof to antigenic proteins and enzymes, antibodies thereto, and related assay methods | SYNTEX (U.S.A.) INC. (US) | 1986-01-08 | — | — | EP | disclosed |