Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.42 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444967 | 0.94 | EDNRB (0.60) | EDNRBRXFP1SMN1; SMN2HPGDPOLB | |
| SCHEMBL8045720 | 0.80 | EDNRB (0.81) | EDNRBRXFP1SMN1; SMN2HPGDPOLB | |
| SCHEMBL7946308 | 0.76 | EDNRB (0.85) | EDNRBRXFP1SMN1; SMN2HPGDPOLB | |
| SCHEMBL7565899 | 0.74 | EDNRB (1.00) | EDNRBRXFP1SMN1; SMN2HPGDPOLB | |
| SCHEMBL7568095 | 0.71 | EDNRB (0.81) | EDNRBRXFP1SMN1; SMN2HPGDPOLB | |
| SCHEMBL8445313 | 0.71 | EDNRB (0.44) | EDNRBSMN1; SMN2HPGDKMT2ANPSR1 | |
| SCHEMBL8443900 | 0.70 | EDNRB (0.47) | EDNRBALDH1A1KDM4E | |
| SCHEMBL7949262 | 0.68 | EDNRB (0.58) | EDNRBSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL12197843 | 0.67 | MAPT (0.74) | RXFP1SMN1; SMN2LMNATHRBAVPR2 | |
| SCHEMBL7565436 | 0.66 | EDNRB (0.82) | EDNRBMAPK1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962682-A | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |