Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 8/20 | 0.76 |
| ▸ | HBB | P68871 | 2/20 | 0.76 |
| ▸ | BLM | P54132 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | EDNRA | P25101 | 1/20 | 0.76 |
| ▸ | HTR2A | P28223 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | HPRT1 | P00492 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | POLG | P54098 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | VCP | P55072 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421280 | 0.97 | PNP (0.79) | PNPHBBBLMTSHRUSP2 | |
| SCHEMBL29370760 | 0.92 | PNP (0.87) | PNPHBBBLMTSHRUSP2 | |
| SCHEMBL8665621 | 0.92 | PNP (0.71) | PNPHBBBLMTSHRUSP2 | |
| SCHEMBL12786355 | 0.90 | PNP (0.76) | PNPHBBBLMTSHRUSP2 | |
| SCHEMBL11730981 | 0.89 | PNP (0.95) | PNPHBBBLMTSHRUSP2 | |
| SCHEMBL13040195 | 0.89 | PNP (0.77) | PNPHBBBLMTSHRUSP2 | |
| SCHEMBL28721440 | 0.88 | PNP (0.73) | PNPHBBBLMTSHRUSP2 | |
| Acyclovir SCHEMBL9479083 | 0.88 | PNP (0.93) | PNPHBBBLMTSHRUSP2 | |
| SCHEMBL1767748 | 0.87 | PNP (0.74) | PNPHBBBLMTSHRUSP2 | |
| SCHEMBL14757459 | 0.86 | PNP (0.80) | PNPHBBBLMTSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0704445-B1 | Preparation of N-9 substituted guanine compounds | HOFFMANN LA ROCHE (CH) | 1999-04-21 | — | — | EP | disclosed |
| US-5565565-A | Preparation of N-9 substituted guanine compounds | SYNTEX (U.S.A.) INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0704445-A1 | Preparation of N-9 substituted guanine compounds | F. Hoffmann-La Roche AG (CH) | 1996-04-03 | — | — | EP | disclosed |