SCHEMBL8445661

SCHEMBL8445661

COc1nn(C)c(=O)n1-c1ccccc1CO/N=C(/C)c1cccc([Ge](C(F)(F)F)(C(F)(F)F)C(F)(F)F)c1

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PPARG P37231 4/20 0.33
PPARA Q07869 3/20 0.33
HIF1A Q16665 1/20 0.31
LMNA P02545 1/20 0.30
MAPK1 P28482 1/20 0.30
HTT P42858 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8445662 1.00 PPARG (0.33) PPARGPPARAHIF1ALMNAMAPK1
SCHEMBL119998 0.87 KMT2A (0.37) PPARGPPARALMNA
SCHEMBL119997 0.87 KMT2A (0.37) PPARGPPARALMNA
SCHEMBL29870686 0.87 KMT2A (0.37) PPARGPPARALMNA
SCHEMBL959562 0.87 KMT2A (0.37) PPARGPPARALMNA
SCHEMBL7006649 0.85 KMT2A (0.36) PPARGPPARAHIF1ALMNAMAPK1
SCHEMBL798615 0.84 RXFP1 (0.34) PPARGPPARAHIF1A
SCHEMBL798616 0.84 RXFP1 (0.34) PPARGPPARAHIF1A
SCHEMBL8310893 0.82 PPARG (0.31) PPARGPPARA
SCHEMBL8791884 0.81 PPARG (0.39) PPARGPPARAHIF1ALMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934283-A2 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-08-11 EP disclosed
WO-1998005652-A2 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-02-12 WO disclosed