⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445704 | 1.00 | — | — | |
| SCHEMBL39214 | 1.00 | — | — | |
| SCHEMBL28382963 | 0.96 | — | — | |
| Water SCHEMBL28145231 | 0.96 | — | — | |
| Alcohol SCHEMBL4828524 | 0.73 | — | — | |
| SCHEMBL270511 | 0.72 | — | — | |
| SCHEMBL4148800 | 0.72 | — | — | |
| Isobutanol SCHEMBL969 | 0.70 | — | — | |
| SCHEMBL1033934 | 0.70 | — | — | |
| Isobutanol SCHEMBL175952 | 0.70 | TSHR (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1254334-A | Novel terephthalamide derivatives | DONGWHA PHARMACEUTICAL IND CO (KR) | 2000-05-24 | — | — | CN | claimed |
| US-5922871-A | VIRICIDE | DONGWHA PHARMACEUTICAL IND. CO., LTD. (KR) | 1999-07-13 | — | — | US | claimed |
| WO-1998054140-A1 | NOVEL TEREPHTHALAMIDE DERIVATIVES | DONGWHA PHARMACEUTICAL IND. CO., LTD. (KR) | 1998-12-03 | — | — | WO | claimed |
| EP-3298003-B1 | BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2023-04-19 | — | — | EP | disclosed |
| CN-107849015-B | Benzimidazole derivatives as PAD4 inhibitors | 葛兰素知识产权发展有限公司 | 2021-03-19 | — | — | CN | disclosed |
| US-10815218-B2 | Benzoimidazole derivatives as PAD4 inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-10-27 | — | — | US | disclosed |
| US-20200095227-A1 | BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-03-26 | — | — | US | disclosed |
| US-10407407-B2 | Benzoimidazole derivatives as PAD4 inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-09-10 | — | — | US | disclosed |
| CN-110088108-A | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | 利奥制药有限公司 | 2019-08-02 | — | — | CN | disclosed |
| US-20180297983-A1 | BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-10-18 | — | — | US | disclosed |
| US-9937158-B2 | Benzoheterocyclic compounds and use thereof | SHANGHAI KECHOW PHARMA, INC. (CN) | 2018-04-10 | — | — | US | disclosed |
| EP-2804855-A1 | BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF | Tianjin Binjiang Pharma, Inc. (CN) | 2014-11-26 | — | — | EP | disclosed |
| WO-2013107283-A1 | BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF | TIANJIN BINJIANG PHARMA, INC. (CN) | 2013-07-25 | — | — | WO | disclosed |
| CN-101151265-B | Dipeptidyl peptidase-iv inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent | LG LIFE SCIENCES LTD | 2012-11-28 | — | — | CN | disclosed |
| CN-101384603-B | Novel, acyclic substituted furopyrimidine derivatives and use thereof for treating cardiovascular diseases | BAYER SCHERING PHARMA AG | 2012-08-01 | — | — | CN | disclosed |
| CN-101384603-A | Novel, acyclic substituted furopyrimidine derivatives and use thereof for treating cardiovascular diseases | BAYER HEALTHCARE AG (DE) | 2009-03-11 | — | — | CN | disclosed |
| CN-101151265-A | Dipeptidyl peptidase-iv inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent | LG LIFE SCIENCES LTD (KR) | 2008-03-26 | — | — | CN | disclosed |
| CN-1254334-A | Novel terephthalamide derivatives | DONGWHA PHARMACEUTICAL IND CO (KR) | 2000-05-24 | — | — | CN | disclosed |
| US-5922871-A | VIRICIDE | DONGWHA PHARMACEUTICAL IND. CO., LTD. (KR) | 1999-07-13 | — | — | US | disclosed |
| WO-1998054140-A1 | NOVEL TEREPHTHALAMIDE DERIVATIVES | DONGWHA PHARMACEUTICAL IND. CO., LTD. (KR) | 1998-12-03 | — | — | WO | disclosed |