Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.80 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8448329 | 1.00 | ADORA2A (0.80) | ADORA2AMKNK1MKNK2CCNCCDK8 | |
| SCHEMBL8444460 | 0.99 | ADORA2A (0.78) | ADORA2AMKNK1MKNK2CCNCCDK8 | |
| SCHEMBL13284477 | 0.93 | ADORA2A (0.69) | ADORA2AMKNK1MKNK2CYP3A4 | |
| SCHEMBL1355237 | 0.90 | ADORA2A (0.81) | ADORA2AMKNK1MKNK2HPGDSMN1; SMN2 | |
| SCHEMBL1355414 | 0.89 | ADORA2A (1.00) | ADORA2AMKNK1MKNK2HPGDSMN1; SMN2 | |
| SCHEMBL1355635 | 0.89 | ADORA2A (0.80) | ADORA2AMKNK1MKNK2HPGD | |
| SCHEMBL1355307 | 0.89 | ADORA2A (1.00) | ADORA2AMKNK1MKNK2HPGDSMN1; SMN2 | |
| SCHEMBL1354665 | 0.89 | ADORA2A (1.00) | ADORA2AMKNK1MKNK2HPGDSMN1; SMN2 | |
| SCHEMBL1355022 | 0.89 | ADORA2A (0.80) | ADORA2AMKNK1MKNK2HPGDSMN1; SMN2 | |
| SCHEMBL1355331 | 0.89 | ADORA2A (1.00) | ADORA2AMKNK1MKNK2HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010084425-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | DOMAIN THERAPEUTICS (FR) | 2010-07-29 | — | — | WO | disclosed |
| EP-2210891-A1 | New adenosine receptor ligands and uses thereof | Domain Therapeutics (FR) | 2010-07-28 | — | — | EP | disclosed |