Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI2 | P48307 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.40 |
| ▸ | PPM1B | O75688 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PPP1CC | P36873 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PPP5C | P53041 | 2/20 | 0.32 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.32 |
| ▸ | NPY4R | P50391 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL468523 | 1.00 | TFPI2 (0.41) | TFPI2LMNAKDM4EGMNNPMP22 | |
| SCHEMBL9978357 | 1.00 | TFPI2 (0.41) | TFPI2LMNAKDM4EGMNNPMP22 | |
| SCHEMBL468432 | 1.00 | TFPI2 (0.41) | TFPI2LMNAKDM4EGMNNPMP22 | |
| SCHEMBL20679256 | 1.00 | TFPI2 (0.41) | TFPI2LMNAKDM4EGMNNPMP22 | |
| SCHEMBL15378131 | 1.00 | TFPI2 (0.41) | TFPI2LMNAKDM4EGMNNPMP22 | |
| SCHEMBL468430 | 1.00 | TFPI2 (0.41) | TFPI2LMNAKDM4EGMNNPMP22 | |
| SCHEMBL2116961 | 0.87 | TFPI2 (0.37) | TFPI2LMNAKDM4EGMNNPMP22 | |
| SCHEMBL15914393 | 0.87 | TFPI2 (0.37) | TFPI2LMNAKDM4EGMNNPMP22 | |
| SCHEMBL458523 | 0.87 | TFPI2 (0.37) | TFPI2LMNAKDM4EGMNNPMP22 | |
| SCHEMBL15914391 | 0.87 | TFPI2 (0.37) | TFPI2LMNAKDM4EGMNNPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576505-A1 | PROCESS FOR THE PREPARATION OF PLEUROMUTILINS | Nabriva Therapeutics AG (AT) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011146954-A1 | PROCESS FOR THE PREPARATION OF PLEUROMUTILINS | NABRIVA THERAPEUTICS AG (AT) | 2011-12-01 | — | — | WO | disclosed |