Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.63 |
| ▸ | FLT1 | P17948 | 5/20 | 0.63 |
| ▸ | EGFR | P00533 | 11/20 | 0.62 |
| ▸ | ILK | Q13418 | 2/20 | 0.61 |
| ▸ | KDM1A | O60341 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | FLT4 | P35916 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 2/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | FBP1 | P09467 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | BUB1 | O43683 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12200787 | 0.86 | RET (0.74) | KDRFLT1EGFRRETLCK | |
| SCHEMBL16760448 | 0.84 | RET (0.78) | KDRFLT1EGFRFGFR1FLT4 | |
| SCHEMBL20805304 | 0.84 | EGFR (0.77) | KDRFLT1EGFRILKKDM1A | |
| SCHEMBL1507598 | 0.82 | EGFR (0.70) | KDRFLT1EGFRILKKDM1A | |
| Hydrochloric Acid SCHEMBL1507438 | 0.82 | EGFR (0.70) | KDRFLT1EGFRILKKDM1A | |
| SCHEMBL3172507 | 0.82 | EGFR (0.67) | KDRFLT1EGFRILKKDM1A | |
| SCHEMBL18447218 | 0.81 | KDM1A (0.77) | KDRFLT1EGFRILKKDM1A | |
| SCHEMBL5648407 | 0.80 | EGFR (0.65) | KDRFLT1EGFRFGFR1FLT4 | |
| SCHEMBL799667 | 0.80 | EGFR (0.78) | KDRFLT1EGFRILKKDM1A | |
| SCHEMBL4736845 | 0.79 | EGFR (0.66) | KDRFLT1EGFRILKKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433931-B2 | New method for the preparation of erlotinib | ITALIANA SINT SPA (IT) | 2016-11-02 | — | — | EP | disclosed |
| US-8609841-B2 | Method for the preparation of erlotinib | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2013-12-17 | — | — | US | disclosed |
| EP-2433931-B1 | New method for the preparation of erlotinib | ITALIANA SINT SPA (IT) | 2013-08-21 | — | — | EP | disclosed |
| US-20120095228-A1 | METHOD FOR THE PREPARATION OF ERLOTINIB | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2012-04-19 | — | — | US | disclosed |
| EP-2433931-A1 | New method for the preparation of erlotinib | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2012-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095228-A1 | METHOD FOR THE PREPARATION OF ERLOTINIB | EGFR, ABL1, ERBB2 | KDR 11/4885FLT1 96/4885EGFR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.