Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10281278 | 1.00 | NPC1 (0.76) | NPC1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL10299164 | 1.00 | NPC1 (0.76) | NPC1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL13272185 | 0.90 | NPC1 (0.63) | NPC1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL844873 | 0.90 | NPC1 (0.63) | NPC1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL17474759 | 0.89 | NPC1 (0.80) | NPC1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL17474788 | 0.89 | NPC1 (0.80) | NPC1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL23373363 | 0.88 | NPC1 (0.79) | NPC1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL845258 | 0.88 | MAPK1 (0.60) | NPC1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL845611 | 0.88 | NPC1 (0.59) | NPC1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL1752676 | 0.87 | NPC1 (0.77) | NPC1MEN1KMT2ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |