Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.67 |
| ▸ | KDM1A | O60341 | 2/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.44 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | CCNK | O75909 | 2/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1888629 | 0.99 | HDAC1 (0.66) | HDAC1HDAC3KDM1AHDAC2HDAC10 | |
| Hydrochloric Acid SCHEMBL1888631 | 0.99 | HDAC1 (0.66) | HDAC1HDAC3KDM1AHDAC2HDAC10 | |
| SCHEMBL12438756 | 0.90 | HDAC1 (0.68) | HDAC1HDAC3KDM1AHDAC2HDAC10 | |
| SCHEMBL1885505 | 0.89 | HDAC1 (0.73) | HDAC1HDAC3KDM1AHDAC2HDAC10 | |
| Hydrochloric Acid SCHEMBL1889089 | 0.89 | HDAC1 (0.67) | HDAC1HDAC3KDM1AHDAC2HDAC10 | |
| SCHEMBL1885509 | 0.89 | HDAC1 (0.73) | HDAC1HDAC3KDM1AHDAC2HDAC10 | |
| Hydrochloric Acid SCHEMBL1889091 | 0.89 | HDAC1 (0.67) | HDAC1HDAC3KDM1AHDAC2HDAC10 | |
| SCHEMBL3432084 | 0.81 | HDAC1 (0.81) | HDAC1HDAC3KDM1AHDAC2HDAC10 | |
| Domatinostat SCHEMBL1613939 | 0.81 | HDAC1 (1.00) | HDAC1HDAC3KDM1AHDAC2HDAC10 | |
| SCHEMBL3432086 | 0.81 | HDAC1 (0.81) | HDAC1HDAC3KDM1AHDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785659-B2 | Method for the production of sulphonylpyrroles as HDAC inhibitors | 4SC AG (DE) | 2014-07-22 | — | — | US | disclosed |
| US-8785659-B2 | Method for the production of sulphonylpyrroles as HDAC inhibitors | 4SC AG (DE) | 2014-07-22 | — | — | US | disclosed |
| US-20110105568-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105568-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2011-05-05 | — | — | US | disclosed |
| WO-2009112529-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| EP-2100878-A1 | Novel method for the production of sulphonylpyrroles as HDAC inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105568-A1 | NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS | HDAC1, HDAC2, HDAC3 | HDAC1 1/4885HDAC3 3/4885KDM1A 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.