Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 10/20 | 0.73 |
| ▸ | F2 | P00734 | 1/20 | 0.68 |
| ▸ | PLG | P00747 | 1/20 | 0.68 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.68 |
| ▸ | C1S | P09871 | 1/20 | 0.68 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | F10 | P00742 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14599540 | 0.87 | PRSS1 (0.88) | PRSS1F2PLGPRSS2C1S | |
| SCHEMBL14599539 | 0.84 | PRSS1 (1.00) | PRSS1F2PLGPRSS2C1S | |
| SCHEMBL12989513 | 0.84 | PRSS1 (1.00) | PRSS1F2PLGPRSS2C1S | |
| SCHEMBL14599537 | 0.84 | PRSS1 (1.00) | PRSS1F2PLGPRSS2C1S | |
| SCHEMBL14131782 | 0.84 | F10 (0.86) | PRSS1F2PLGPRSS2C1S | |
| SCHEMBL13813622 | 0.83 | PRSS1 (0.81) | PRSS1F2PLGPRSS2C1S | |
| SCHEMBL14132297 | 0.81 | PRSS1 (0.73) | PRSS1F2PLGPRSS2C1S | |
| SCHEMBL11737749 | 0.81 | MAOB (0.69) | PRSS1F2PLGPRSS2C1S | |
| SCHEMBL29079516 | 0.80 | PRSS1 (0.85) | PRSS1F2PLGPRSS2C1S | |
| SCHEMBL12989612 | 0.80 | PRSS1 (0.90) | PRSS1F2PLGPRSS2C1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625138-B1 | NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS WITH LTB4 ANTAGONISTIC EFFECT | BOEHRINGER INGELHEIM INT (DE) | 1999-06-02 | — | — | EP | disclosed |
| EP-0902013-A1 | Novel amidine derivatives, their preparation and their use as medicaments with LTB-4 antagonistic effect | BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) | 1999-03-17 | — | — | EP | disclosed |
| EP-0625138-A1 | NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDIAMENTS WITH LTB-4 ANTAGONISTIC EFFECT | BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993016036-A1 | NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDIAMENTS WITH LTB-4 ANTAGONISTIC EFFECT | BOEHRINGER INGELHEIM KG (DE) | 1993-08-19 | — | — | WO | disclosed |