Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 13/20 | 0.59 |
| ▸ | FNTB | P49356 | 12/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8453359 | 1.00 | FNTA (0.59) | FNTAFNTBPARP1PGGT1BALDH1A1 | |
| SCHEMBL5740245 | 0.91 | FNTA (0.51) | FNTAFNTBPARP1PGGT1BALDH1A1 | |
| SCHEMBL5740252 | 0.91 | FNTA (0.51) | FNTAFNTBPARP1PGGT1BALDH1A1 | |
| SCHEMBL8574801 | 0.91 | FNTA (0.51) | FNTAFNTBPARP1PGGT1BALDH1A1 | |
| SCHEMBL8576632 | 0.90 | FNTA (0.57) | FNTAFNTBPARP1PGGT1BALDH1A1 | |
| SCHEMBL8390112 | 0.89 | FNTA (0.62) | FNTAFNTBPARP1PGGT1BALDH1A1 | |
| SCHEMBL8390110 | 0.89 | FNTA (0.62) | FNTAFNTBPARP1PGGT1BALDH1A1 | |
| SCHEMBL8574812 | 0.89 | PARP1 (0.51) | FNTAFNTBPARP1PGGT1BALDH1A1 | |
| SCHEMBL8574809 | 0.89 | PARP1 (0.51) | FNTAFNTBPARP1PGGT1BALDH1A1 | |
| SCHEMBL8572840 | 0.88 | FNTA (0.49) | FNTAFNTBPARP1PGGT1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856326-A | ANTITUMOR, ANTICANCER AGENTS | MERCK & CO., INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5736539-A | ANITCARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1998-04-07 | — | — | US | disclosed |
| EP-0820445-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996030343-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |
| EP-0703905-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1995000497-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1995-01-05 | — | — | WO | disclosed |