Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 13/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3601568 | 0.95 | KDM1A (0.41) | KDM1AMAOBNPC1RXFP1PTPN1 | |
| Trifluoroacetic Acid SCHEMBL3601567 | 0.95 | KDM1A (0.41) | KDM1AMAOBNPC1RXFP1PTPN1 | |
| SCHEMBL8446370 | 0.87 | KDM1A (0.45) | KDM1AMAOBNPC1RXFP1PTPN1 | |
| SCHEMBL13550257 | 0.84 | KDM1A (0.43) | KDM1AMAOBNPC1RXFP1PTPN1 | |
| SCHEMBL13550258 | 0.84 | KDM1A (0.43) | KDM1AMAOBNPC1RXFP1PTPN1 | |
| SCHEMBL4448506 | 0.82 | KDM1A (0.44) | KDM1AMAOBNPC1RXFP1PTPN1 | |
| SCHEMBL16142526 | 0.82 | KDM1A (0.44) | KDM1AMAOBNPC1RXFP1PTPN1 | |
| SCHEMBL4556608 | 0.82 | KDM1A (0.44) | KDM1AMAOBNPC1RXFP1PTPN1 | |
| SCHEMBL3600203 | 0.81 | KDM1A (0.49) | KDM1AMAOBNPC1RXFP1PTPN1 | |
| SCHEMBL3605976 | 0.81 | KDM1A (0.49) | KDM1AMAOBNPC1RXFP1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121612-B1 | HETEROARYLCYCLOPROPANECARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2014-10-01 | — | — | EP | disclosed |
| WO-2008080511-A1 | HETEROARYLCYCLOPROPANECARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2008-07-10 | — | — | WO | disclosed |
| EP-1942104-A1 | Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals | sanofi-aventis (FR) | 2008-07-09 | — | — | EP | disclosed |