SCHEMBL8455482

SCHEMBL8455482

CC[C@H]1CC[C@H](CCC2CCC(c3ccc(-c4ccc(Cl)cc4)c(F)c3)CC2)CC1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.40
CYP2C9 P11712 3/20 0.40
FASN P49327 1/20 0.38
APP P05067 2/20 0.37
OPRL1 P41146 5/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
DRD2 P14416 1/20 0.36
ESR2 Q92731 1/20 0.35
CRHR1 P34998 1/20 0.34
DGAT1 O75907 1/20 0.33
SOAT1 P35610 1/20 0.33
TRPV3 Q8NET8 1/20 0.33
ALOX5AP P20292 1/20 0.33
FEN1 P39748 1/20 0.33
CNR1 P21554 1/20 0.33
KDM1A O60341 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8455485 1.00 CYP3A4 (0.40) CYP3A4CYP2C9FASNAPPOPRL1
SCHEMBL8455476 1.00 CYP3A4 (0.40) CYP3A4CYP2C9FASNAPPOPRL1
SCHEMBL8451772 0.93 CYP2C9 (0.41) CYP3A4CYP2C9FASNAPPOPRL1
SCHEMBL8451765 0.93 CYP2C9 (0.41) CYP3A4CYP2C9FASNAPPOPRL1
SCHEMBL8451769 0.93 CYP2C9 (0.41) CYP3A4CYP2C9FASNAPPOPRL1
SCHEMBL8857781 0.91 CYP2C9 (0.42) CYP3A4CYP2C9FASNAPPOPRL1
SCHEMBL8857786 0.91 CYP2C9 (0.42) CYP3A4CYP2C9FASNAPPOPRL1
SCHEMBL8453541 0.90 CYP2C9 (0.38) CYP3A4CYP2C9FASNAPPOPRL1
SCHEMBL8453543 0.90 CYP2C9 (0.38) CYP3A4CYP2C9FASNAPPOPRL1
SCHEMBL8453546 0.90 CYP2C9 (0.38) CYP3A4CYP2C9FASNAPPOPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5858275-A Chlorobenzene derivative and liquid crystal composition containing the same CHISSO CORPORATION (JP) 1999-01-12 US disclosed
EP-0785179-A1 CHLOROBENZENE DERIVATIVE AND LIQUID-CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORPORATION (JP) 1997-07-23 EP disclosed