Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.30 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845386 | 0.86 | AAK1 (0.31) | — | |
| SCHEMBL30529332 | 0.84 | CCR1 (0.50) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL748190 | 0.84 | CCR1 (0.50) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL30296292 | 0.77 | CCR1 (0.41) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL845889 | 0.71 | CCR1 (0.39) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL845890 | 0.71 | CCR1 (0.39) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL2894661 | 0.71 | CCR1 (0.45) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL1637824 | 0.69 | CCR1 (0.47) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL30236447 | 0.69 | AAK1 (0.38) | — | |
| SCHEMBL29953562 | 0.69 | CCR1 (0.47) | CCR1CCR5CCR8TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |