Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 12/20 | 0.76 |
| ▸ | PPARG | P37231 | 1/20 | 0.66 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458069 | 1.00 | HPGD (0.76) | HPGDPPARGCISD1PTPN1POLB | |
| SCHEMBL9311896 | 0.87 | HPGD (0.58) | HPGDPPARGCISD1PTPN1POLB | |
| SCHEMBL1300345 | 0.87 | HPGD (1.00) | HPGDCISD1PTPN1POLBMAOA | |
| SCHEMBL1300347 | 0.87 | HPGD (1.00) | HPGDCISD1PTPN1POLBMAOA | |
| SCHEMBL6866778 | 0.87 | HPGD (1.00) | HPGDCISD1PTPN1POLBMAOA | |
| SCHEMBL6381881 | 0.82 | HPGD (0.77) | HPGDCISD1PTPN1PIM1PIM2 | |
| SCHEMBL6381880 | 0.82 | HPGD (0.77) | HPGDCISD1PTPN1PIM1PIM2 | |
| SCHEMBL9326177 | 0.81 | HPGD (0.80) | HPGDCISD1PTPN1POLBMAOA | |
| SCHEMBL9326976 | 0.81 | HPGD (0.80) | HPGDCISD1PTPN1POLBMAOA | |
| SCHEMBL9311521 | 0.81 | HPGD (0.69) | HPGDPPARGCISD1PTPN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999059586-A1 | THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-25 | — | — | WO | claimed |
| WO-1999059586-A1 | THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-25 | — | — | WO | disclosed |
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5296605-A | 2,4-thiazolidinedione compounds | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |