Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | ESR1 | P03372 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL929970 | 0.91 | GRM5 (0.59) | GRM5ESR2ALDH1A1TDP1POLB | |
| SCHEMBL927271 | 0.90 | GRM5 (0.47) | GRM5ESR2ALDH1A1TDP1POLB | |
| SCHEMBL929349 | 0.89 | GRM5 (0.57) | GRM5ESR2ALDH1A1TDP1POLB | |
| SCHEMBL928643 | 0.89 | GRM5 (0.56) | GRM5ESR2ALDH1A1TDP1POLB | |
| SCHEMBL928524 | 0.87 | GRM5 (0.55) | GRM5ESR2ALDH1A1TDP1POLB | |
| SCHEMBL928802 | 0.86 | GRM5 (0.54) | GRM5ESR2ALDH1A1TDP1POLB | |
| SCHEMBL928889 | 0.86 | GRM5 (0.54) | GRM5ESR2ALDH1A1TDP1POLB | |
| SCHEMBL13720090 | 0.85 | NOTUM (0.40) | GRM5ESR2ALDH1A1TDP1POLB | |
| SCHEMBL928186 | 0.85 | GRM5 (0.48) | GRM5ESR2ALDH1A1TDP1POLB | |
| SCHEMBL929479 | 0.85 | GRM5 (0.53) | GRM5ESR2ALDH1A1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2085398-A1 | Pyrazolopyrimidines, a process for their preparation and their use as medicine | Merz Pharma GmbH & Co. KGaA (DE) | 2009-08-05 | — | — | EP | disclosed |