L-708568

L-708568

SCHEMBL8459442

CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 1.00
KDM4E B2RXH2 1/20 0.75
MEN1 O00255 1/20 0.75
ALDH1A1 P00352 1/20 0.75
LMNA P02545 1/20 0.75
TP53 P04637 1/20 0.75
CYP1A2 P05177 1/20 0.75
POLB P06746 1/20 0.75
CYP3A4 P08684 1/20 0.75
CYP2D6 P10635 1/20 0.75
MAPT P10636 1/20 0.75
CYP2C9 P11712 1/20 0.75
NFKB1 P19838 1/20 0.75
APEX1 P27695 1/20 0.75
CYP2C19 P33261 1/20 0.75
THPO P40225 1/20 0.75
BLM P54132 1/20 0.75
KMT2A Q03164 1/20 0.75
NPSR1 Q6W5P4 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9257911 0.91 TACR1 (1.00) TACR1KDM4EMEN1ALDH1A1LMNA
SCHEMBL9266038 0.91 TACR1 (0.83) TACR1KDM4EMEN1ALDH1A1LMNA
SCHEMBL17131465 0.91 TACR1 (0.90) TACR1KDM4EMEN1ALDH1A1LMNA
SCHEMBL9262302 0.90 TACR1 (1.00) TACR1KDM4EMEN1ALDH1A1LMNA
SCHEMBL9266278 0.89 TACR1 (0.80) TACR1KDM4EMEN1ALDH1A1LMNA
SCHEMBL30625884 0.89 TACR1 (0.80) TACR1KDM4EMEN1ALDH1A1LMNA
SCHEMBL9261932 0.89 TACR1 (1.00) TACR1
SCHEMBL9262070 0.87 TACR1 (1.00) TACR1KDM4EMEN1ALDH1A1LMNA
L-732138 SCHEMBL9272011 0.86 TACR1 (1.00) TACR1KDM4EMEN1ALDH1A1LMNA
L-732138 SCHEMBL29374396 0.86 TACR1 (1.00) TACR1KDM4EMEN1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999007413-A1 SUBSTANCE P INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN ALGOS PHARMACEUTICAL CORPORATION (US) 1999-02-18 WO claimed
US-5472978-A Tachykinin antagonists for treating pain, migraine and antiinflammatory agents MERCK SHARP & DOHME LTD. (GB) 1995-12-05 US claimed
WO-1993001169-A2 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME LIMITED (GB) 1993-01-21 WO claimed
WO-1999007413-A1 SUBSTANCE P INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN ALGOS PHARMACEUTICAL CORPORATION (US) 1999-02-18 WO disclosed
US-5472978-A Tachykinin antagonists for treating pain, migraine and antiinflammatory agents MERCK SHARP & DOHME LTD. (GB) 1995-12-05 US disclosed
EP-0593559-A1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME LTD. (GB) 1994-04-27 EP disclosed
WO-1993001169-A2 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME LIMITED (GB) 1993-01-21 WO disclosed