Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13991733 | 1.00 | TRPV1 (0.72) | TRPV1HDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL845900 | 0.99 | TRPV1 (0.72) | TRPV1HDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL846111 | 0.92 | TRPV1 (0.70) | TRPV1HDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL846227 | 0.90 | TRPV1 (0.61) | TRPV1HDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL846492 | 0.89 | TRPV1 (0.74) | TRPV1HDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL845819 | 0.88 | MEN1 (0.59) | TRPV1HDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL846333 | 0.88 | TRPV1 (0.74) | TRPV1HDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL1577038 | 0.87 | TRPV1 (0.76) | TRPV1HDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL846538 | 0.84 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL846224 | 0.84 | TRPV1 (1.00) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |