Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845931 | 0.80 | TRPV1 (0.80) | NPC1RAB9ATRPV1MAPT | |
| SCHEMBL30824493 | 0.79 | PDE10A (0.59) | NPC1RAB9APDE10A | |
| SCHEMBL6257291 | 0.76 | NPC1 (1.00) | NPC1RAB9AMTORADORA3ADORA2A | |
| SCHEMBL12204397 | 0.75 | NPC1 (1.00) | NPC1RAB9AMTORADORA3ADORA2A | |
| SCHEMBL5091480 | 0.73 | NPC1 (0.77) | NPC1RAB9AMTORADORA3ADORA2A | |
| SCHEMBL15931641 | 0.73 | NPC1 (1.00) | NPC1RAB9AMTORADORA3ADORA2A | |
| SCHEMBL860630 | 0.72 | NPC1 (0.54) | NPC1RAB9AMTORADORA3ADORA2A | |
| SCHEMBL19616650 | 0.71 | NPC1 (0.74) | NPC1RAB9AMTORADORA3ADORA2A | |
| SCHEMBL4433745 | 0.71 | NPC1 (0.73) | NPC1RAB9AMTORADORA3ADORA2A | |
| SCHEMBL31725147 | 0.71 | NPC1 (0.74) | NPC1RAB9AMTORADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |