Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.74 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846740 | 0.93 | TRPV1 (0.72) | TRPV1KDRTMPRSS4 | |
| SCHEMBL846823 | 0.85 | TRPV1 (1.00) | TRPV1KDR | |
| SCHEMBL846831 | 0.84 | TRPV1 (1.00) | TRPV1KDR | |
| SCHEMBL847376 | 0.84 | TRPV1 (1.00) | TRPV1KDR | |
| SCHEMBL846722 | 0.84 | TRPV1 (0.73) | TRPV1KDR | |
| SCHEMBL846538 | 0.84 | TRPV1 (1.00) | TRPV1KDR | |
| SCHEMBL846224 | 0.84 | TRPV1 (1.00) | TRPV1KDR | |
| SCHEMBL846048 | 0.84 | TRPV1 (1.00) | TRPV1KDR | |
| SCHEMBL845893 | 0.83 | TRPV1 (0.81) | TRPV1KDR | |
| SCHEMBL846592 | 0.83 | TRPV1 (0.73) | TRPV1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |