Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.58 |
| ▸ | BCHE | P06276 | 3/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846403 | 0.90 | KDR (0.72) | KDRSMN1; SMN2MAPK1TRPV1HSD17B10 | |
| SCHEMBL846001 | 0.86 | KDR (0.58) | KDRMAPTTRPV1KDM4ENPC1 | |
| SCHEMBL845964 | 0.85 | KDR (0.68) | KDRMAPTSMN1; SMN2TRPV1HSD17B10 | |
| SCHEMBL846604 | 0.84 | KDR (0.58) | KDRMAPTSMN1; SMN2TRPV1KDM4E | |
| SCHEMBL848116 | 0.84 | NPC1 (0.65) | KDRTRPV1KDM4ENPC1MITF | |
| SCHEMBL846030 | 0.84 | KDR (0.67) | KDRMAPTSMN1; SMN2MAPK1TRPV1 | |
| SCHEMBL846379 | 0.84 | KDR (0.67) | KDRMAPTSMN1; SMN2MAPK1TRPV1 | |
| SCHEMBL846074 | 0.84 | KDR (0.67) | KDRMAPTSMN1; SMN2MAPK1TRPV1 | |
| SCHEMBL846300 | 0.84 | KDR (0.67) | KDRMAPTSMN1; SMN2MAPK1TRPV1 | |
| SCHEMBL845220 | 0.83 | NPC1 (0.66) | KDRMAPTSMN1; SMN2MAPK1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |