Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.51 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 10/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670697 | 0.80 | SMN1; SMN2 (0.60) | P2RX7EPHX2SMN1; SMN2 | |
| SCHEMBL8854765 | 0.77 | GAA (0.70) | LSSP2RX7PPARASMN1; SMN2 | |
| SCHEMBL10425483 | 0.77 | SMN1; SMN2 (0.67) | LSSSORT1P2RX7PPARAPPARG | |
| SCHEMBL17038830 | 0.75 | FSCN1 (0.67) | HDAC6HDAC1 | |
| SCHEMBL30501138 | 0.75 | FSCN1 (0.67) | HDAC6HDAC1 | |
| SCHEMBL13947580 | 0.74 | LSS (0.72) | LSSPPARAPPARGEPHX2SMN1; SMN2 | |
| SCHEMBL23187971 | 0.74 | FLT1 (0.40) | P2RX7HDAC6KDM1AHDAC1 | |
| SCHEMBL17038803 | 0.73 | FSCN1 (0.55) | — | |
| SCHEMBL30695005 | 0.73 | FSCN1 (0.55) | — | |
| SCHEMBL1695141 | 0.72 | MTOR (0.58) | LSSSORT1P2RX7PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958959-A | ADMINISTERING 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID-(4-TRIFLUOROMETHYL)ANILIDE OR 2-CYANO-3-HYDROXY-N-(4-(TRIFLUOROMETHYL)PHENYL)-2-BUTENAMIDE | SUGEN, INC. (US) | 1999-09-28 | — | — | US | disclosed |