SCHEMBL8464967

SCHEMBL8464967

O=C1C(=O)c2c(nc3ccccn23)-c2cccc(Br)c21

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.61
HSP90AB1 P08238 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8464828 0.84 HSP90AA1 (0.61) HSP90AA1HSP90AB1
SCHEMBL8466674 0.84 HSP90AA1 (0.61) HSP90AA1HSP90AB1
SCHEMBL8464843 0.84 HSP90AA1 (0.61) HSP90AA1HSP90AB1
SCHEMBL8465216 0.81 HSP90AA1 (0.79) HSP90AA1HSP90AB1
SCHEMBL8465017 0.80 HSP90AA1 (0.56) HSP90AA1HSP90AB1
SCHEMBL1274825 0.76 HSP90AA1 (1.00) HSP90AA1HSP90AB1
SCHEMBL8465132 0.76 HSP90AA1 (0.61) HSP90AA1HSP90AB1
SCHEMBL31237216 0.76 HSP90AA1 (0.61) HSP90AA1HSP90AB1
SCHEMBL8465070 0.76 HSP90AA1 (0.61) HSP90AA1HSP90AB1
SCHEMBL8467806 0.75 HSP90AA1 (0.64) HSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US claimed
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US disclosed