Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.78 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.68 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 5/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8158688 | 0.89 | CYP26A1 (0.86) | CYP19A1CYP26A1CYP24A1ESR1ESR2 | |
| SCHEMBL8466193 | 0.87 | CYP19A1 (0.60) | CYP19A1CYP26A1CYP24A1SIGMAR1 | |
| SCHEMBL29679345 | 0.86 | CYP19A1 (0.59) | CYP19A1CYP26A1CYP24A1HTR1ASIGMAR1 | |
| SCHEMBL28733931 | 0.86 | CYP19A1 (0.59) | CYP19A1CYP26A1CYP24A1HTR1ASIGMAR1 | |
| SCHEMBL10686519 | 0.86 | CYP19A1 (0.59) | CYP19A1CYP26A1CYP24A1HTR1ASIGMAR1 | |
| SCHEMBL29679745 | 0.83 | CYP19A1 (0.57) | CYP19A1CYP26A1CYP24A1HTR1ASIGMAR1 | |
| SCHEMBL28733980 | 0.83 | CYP19A1 (0.57) | CYP19A1CYP26A1CYP24A1HTR1ASIGMAR1 | |
| SCHEMBL28733983 | 0.83 | CYP19A1 (0.57) | CYP19A1CYP26A1CYP24A1HTR1ASIGMAR1 | |
| SCHEMBL28733973 | 0.83 | CYP19A1 (0.57) | CYP19A1CYP26A1CYP24A1HTR1ASIGMAR1 | |
| SCHEMBL29679305 | 0.83 | CYP19A1 (0.57) | CYP19A1CYP26A1CYP24A1HTR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| CN-1021823-C | Substituted chroman compounds for treatment of asthma, arthritis and the like | PFIZER (US) | 1993-08-18 | — | — | CN | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| CN-1064864-A | The tetraline that replaces and the preparation method of allied compound | PFIZER (US) | 1992-09-30 | — | — | CN | disclosed |
| CN-1063489-A | Substituted benzotetrahydropyridines and related compounds | PFIZER (US) | 1992-08-12 | — | — | CN | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| CN-1032659-A | Substituted tetralins, chromans and like compounds for the treatment of asthma, arthritis and like diseases | PFIZER (US) | 1989-05-03 | — | — | CN | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |