Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.45 |
| ▸ | FDPS | P14324 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8466474 | 1.00 | TSHR (0.52) | TSHRALDH1A1SMPD1FDPSTDP1 | |
| Bromide SCHEMBL8468369 | 0.95 | TSHR (0.59) | TSHRALDH1A1SMPD1FDPSTDP1 | |
| SCHEMBL15901461 | 0.88 | TSHR (0.48) | TSHRALDH1A1SMPD1FDPSTDP1 | |
| SCHEMBL15901071 | 0.88 | TSHR (0.48) | TSHRALDH1A1SMPD1FDPSTDP1 | |
| SCHEMBL15901110 | 0.88 | TSHR (0.48) | TSHRALDH1A1SMPD1FDPSTDP1 | |
| Bromide SCHEMBL6258453 | 0.88 | SMPD1 (0.48) | TSHRALDH1A1SMPD1FDPSDNM1 | |
| Bromide SCHEMBL5088567 | 0.88 | SMPD1 (0.48) | TSHRALDH1A1SMPD1FDPSDNM1 | |
| Bromide SCHEMBL10696126 | 0.88 | SMPD1 (0.48) | TSHRALDH1A1SMPD1FDPSDNM1 | |
| Bromide SCHEMBL10693787 | 0.88 | SMPD1 (0.48) | TSHRALDH1A1SMPD1FDPSDNM1 | |
| Bromide SCHEMBL19329912 | 0.88 | SMPD1 (0.48) | TSHRALDH1A1SMPD1FDPSDNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5969090-A | QUATERNIZED CROSSLINKED HYDROCARBON AMINE POLYMER | GELTEX PHARMACEUTICALS, INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5900475-A | MODIFIED POLYALLYLAMINE; ANTICHOLESTEROL AGENT | GELTEX PHARMACEUTICALS, INC. (US) | 1999-05-04 | — | — | US | disclosed |
| EP-0830390-A1 | HYDROPHOBIC HETEROATOM-CONTAINING SEQUESTRANT FOR CHOLESTEROL DEPLETION | GELTEX PHARMACEUTICALS, INC. (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996039449-A1 | HYDROPHOBIC HETEROATOM-CONTAINING SEQUESTRANT FOR CHOLESTEROL DEPLETION | GELTEX PHARMACEUTICALS, INC. (US) | 1996-12-12 | — | — | WO | disclosed |