Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.62 |
| ▸ | FPR2 | P25090 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443694 | 1.00 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL7443689 | 1.00 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL2906838 | 0.89 | PDE4D (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2906837 | 0.89 | PDE4D (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8466408 | 0.89 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL7450391 | 0.89 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL7450388 | 0.89 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL5823060 | 0.83 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL7442784 | 0.83 | PDE4B (0.66) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8462529 | 0.81 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745063-B1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PROD (US) | 1999-03-24 | — | — | EP | claimed |