SCHEMBL8466911

SCHEMBL8466911

N=C(N)NCCC[C@@H](NC(=O)OCCCCCn1cnc2c(O)ncnc21)C(=O)O

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ADCY5 O95622 4/20 0.37
ITGB3 P05106 2/20 0.32
ADCY1 Q08828 1/20 0.32
ITGA2B P08514 1/20 0.32
ALDH1A1 P00352 1/20 0.32
ADORA2A P29274 1/20 0.32
PLA2G2A P14555 1/20 0.32
HDAC1 Q13547 2/20 0.32
HDAC2 Q92769 2/20 0.32
TRPM2 O94759 1/20 0.32
ITGAV P06756 1/20 0.31
PDE3A Q14432 1/20 0.31
MARS1 P56192 1/20 0.31
NPY4R P50391 2/20 0.31
P2RY1 P47900 1/20 0.31
NPY1R P25929 1/20 0.31
PRKACA P17612 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10534213 0.93 NPY4R (0.36) NPY4RNPY1RPRKACA
SCHEMBL8466600 0.92 ADCY5 (0.47) ADCY5ADCY1ALDH1A1ADORA2APLA2G2A
SCHEMBL8465859 0.92 ADCY5 (0.47) ADCY5ADCY1ALDH1A1ADORA2APLA2G2A
SCHEMBL8464251 0.91 ADCY5 (0.36) ADCY5ITGB3ADCY1ITGA2B
SCHEMBL8466905 0.91 ADCY5 (0.36) ADCY5ITGB3ADCY1ITGA2B
SCHEMBL8467662 0.91 ADCY5 (0.36) ADCY5ITGB3ADCY1ITGA2BALDH1A1
SCHEMBL8467714 0.91 ADCY5 (0.36) ADCY5ITGB3ADCY1ITGA2BALDH1A1
SCHEMBL9561047 0.91 ADCY5 (0.35) ADCY5ALDH1A1PLA2G2AMARS1NPY4R
SCHEMBL8465925 0.91 ADCY5 (0.36) ADCY5ITGB3ADCY1ITGA2BALDH1A1
SCHEMBL8467074 0.90 P2RY1 (0.43) ADCY5HDAC1HDAC2PDE3AMARS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994361-A ANTITUMOR, ANTICANCER AGENT BIOCHEM PHARMA (CA) 1999-11-30 US claimed