⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29376431 | 0.75 | — | — | |
| SCHEMBL17297299 | 0.75 | — | — | |
| SCHEMBL12260190 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL28088470 | 0.62 | PDE3B (0.33) | — | |
| SCHEMBL18280199 | 0.62 | — | — | |
| SCHEMBL388290 | 0.60 | — | — | |
| SCHEMBL19239761 | 0.60 | — | — | |
| SCHEMBL16612316 | 0.55 | — | — | |
| SCHEMBL30375761 | 0.55 | — | — | |
| SCHEMBL1313095 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228469-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-07-11 | — | — | US | disclosed |
| US-20240217951-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-07-04 | — | — | US | disclosed |
| US-11912714-B2 | Spiropyrrolidine derived antiviral agents | ENANTA PHARMACEUTICALS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11858945-B2 | Alkyne-containing antiviral agents | ENANTA PHARMACEUTICALS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-20230365525-A1 | ANTIVIRAL COMPOUNDS | ENANTA PHARMACEUTICALS, INC. | 2023-11-16 | — | — | US | disclosed |
| US-20230331734-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2023-10-19 | — | — | US | disclosed |
| US-20230271949-A1 | GLP-1R MODULATING COMPOUNDS | ASCLETIS BIOSCIENCE CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
| US-11738019-B2 | Substituted heterocycles as antiviral agents | ENANTA PHARMACEUTICALS, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20230234958-A1 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | D. E. SHAW RESEARCH, LLC | 2023-07-27 | — | — | US | disclosed |
| US-20230192703-A1 | Polycyclic amide derivative as CDK9 inhibitor, preparation method therefor and use thereof | Suzhou Alphama Biotechnology Co., Ltd. (CN) | 2023-06-22 | — | — | US | disclosed |
| US-20050043311-A1 | Optically active 5H-pyrrolo[3,4-b] pyrazine derivative, its preparation and pharmaceutical compositions containing same | SEPRACOR INC. (US) | 2005-02-24 | — | — | US | disclosed |
| US-20050043311-A1 | Optically active 5H-pyrrolo[3,4-b] pyrazine derivative, its preparation and pharmaceutical compositions containing same | SEPRACOR INC. (US) | 2005-02-24 | — | — | US | disclosed |
| US-20020193378-A1 | Optically active 5H-pyrrolo[3,4-b]pyrazine derivative, its preparation and pharmaceutical compositions containing it | SEPRACOR INC. | 2002-12-19 | — | — | US | disclosed |
| US-20020193378-A1 | Optically active 5H-pyrrolo[3,4-b]pyrazine derivative, its preparation and pharmaceutical compositions containing it | SEPRACOR INC. | 2002-12-19 | — | — | US | disclosed |
| US-6444673-B1 | Optically active 5H-pyrrolo[3,4-b]pyrazine derivative, its preparation and pharmaceutical compositions containing it | SEPRACOR INC. | 2002-09-03 | — | — | US | disclosed |
| US-6444673-B1 | Optically active 5H-pyrrolo[3,4-b]pyrazine derivative, its preparation and pharmaceutical compositions containing it | SEPRACOR INC. | 2002-09-03 | — | — | US | disclosed |
| US-6319926-B1 | Optically active 5H-pyrrolo[3, 4-B]pyrazine derivative, its preparation and pharmaceutical compositions containing it | SEPRACOR INC. | 2001-11-20 | — | — | US | disclosed |
| EP-0609210-B1 | OPTICALLY ACTIVE 5H-PYRROLO[3,4-b]PYRAZINE DERIVATIVE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | RHONE POULENC RORER SA (FR) | 1995-04-12 | — | — | EP | disclosed |
| EP-0495717-A1 | Optically active derivative of 5-H-pyrrolo(3,4-B)pyrazine, its preparation and pharmaceutical compositions containing it | Aventis Pharma S.A. (FR) | 1992-07-22 | — | — | EP | disclosed |
| EP-0495717-A1 | Optically active derivative of 5-H-pyrrolo(3,4-B)pyrazine, its preparation and pharmaceutical compositions containing it | Aventis Pharma S.A. (FR) | 1992-07-22 | — | — | EP | disclosed |