Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 4/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13505038 | 0.82 | PDPK1 (0.45) | BRD4GRM2 | |
| SCHEMBL3348835 | 0.79 | BRD4 (0.38) | BRD4GRM2METALOX5APFEN1 | |
| SCHEMBL3354820 | 0.79 | ALK (0.60) | ALKAXL | |
| SCHEMBL8481417 | 0.78 | BRD4 (0.50) | BRD4PIM1GRM2METAP2ALOX5AP | |
| SCHEMBL4403657 | 0.76 | BRD4 (0.49) | BRD4PIM1ALOX5APFEN1CREBBP | |
| SCHEMBL16374539 | 0.71 | TYRO3 (0.41) | BRD4CREBBPAXL | |
| SCHEMBL13505488 | 0.71 | — | — | |
| SCHEMBL8445021 | 0.70 | BRD4 (0.43) | BRD4PIM1GRM2CREBBPSMARCA2 | |
| SCHEMBL8445036 | 0.69 | MAPK8 (0.39) | — | |
| SCHEMBL8442728 | 0.68 | ALK (0.61) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |