Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.45 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371419 | 1.00 | HCRTR1 (0.50) | HCRTR1HCRTR2TSHRCYP2C9CYP2C19 | |
| SCHEMBL8471226 | 0.90 | F10 (0.54) | HCRTR1HCRTR2TSHRCYP2C9CYP2C19 | |
| SCHEMBL15436018 | 0.90 | F10 (0.48) | HCRTR1HCRTR2TSHRNPC1RAB9A | |
| SCHEMBL12371451 | 0.90 | F10 (0.48) | HCRTR1HCRTR2TSHRNPC1RAB9A | |
| SCHEMBL14434220 | 0.90 | NPC1 (0.47) | HCRTR1HCRTR2TSHRCYP2C9CYP2C19 | |
| SCHEMBL12101351 | 0.89 | F10 (0.47) | CYP2C9CYP2C19NPC1RAB9APOLB | |
| SCHEMBL15436217 | 0.89 | NPC1 (0.47) | HCRTR1HCRTR2TSHRNPC1RAB9A | |
| SCHEMBL13104199 | 0.89 | F10 (0.47) | CYP2C9CYP2C19NPC1RAB9APOLB | |
| SCHEMBL12371447 | 0.89 | F10 (0.45) | HCRTR1HCRTR2TSHRCYP2C9CYP2C19 | |
| SCHEMBL12371438 | 0.89 | NPC1 (0.47) | HCRTR1HCRTR2TSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1818330-A1 | Substituted proline amides, preparation and use as medicaments thereof | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2007-08-15 | — | — | EP | disclosed |