Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.42 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371425 | 1.00 | F10 (0.57) | F10POLBKLKB1CYP1A2CYP3A4 | |
| SCHEMBL12371426 | 0.90 | MEN1 (0.53) | F10POLBKLKB1MAPTMEN1 | |
| SCHEMBL12371471 | 0.90 | F10 (0.46) | F10POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8471194 | 0.90 | MEN1 (0.53) | F10POLBKLKB1MAPTMEN1 | |
| SCHEMBL12101338 | 0.87 | MEN1 (0.50) | F10POLBKLKB1MAPTMEN1 | |
| SCHEMBL8471226 | 0.87 | F10 (0.54) | F10POLBKLKB1CYP1A2CYP3A4 | |
| SCHEMBL12371472 | 0.86 | F10 (0.43) | F10POLBKLKB1CYP1A2CYP3A4 | |
| SCHEMBL13104152 | 0.85 | F10 (0.52) | F10POLBKLKB1CYP1A2CYP3A4 | |
| SCHEMBL12101291 | 0.85 | F10 (0.52) | F10POLBKLKB1CYP1A2CYP3A4 | |
| SCHEMBL12101293 | 0.84 | F10 (0.53) | F10POLBKLKB1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1818330-A1 | Substituted proline amides, preparation and use as medicaments thereof | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2007-08-15 | — | — | EP | disclosed |