Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.72 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 6/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605246 | 0.87 | HRH4 (0.67) | HRH4HRH3PARP1PARP2ALOX15 | |
| SCHEMBL602168 | 0.84 | HRH4 (1.00) | HRH4HRH3PARP1PARP2ALOX15 | |
| SCHEMBL604563 | 0.82 | HRH4 (0.75) | HRH4HRH3PARP1PARP2ALOX15 | |
| SCHEMBL602140 | 0.82 | HRH4 (0.75) | HRH4HRH3PARP1PARP2 | |
| SCHEMBL603318 | 0.79 | HRH4 (0.69) | HRH4HRH3PARP1PARP2 | |
| SCHEMBL8475015 | 0.77 | PARP1 (0.46) | HRH4PARP1 | |
| SCHEMBL604426 | 0.77 | HRH4 (1.00) | HRH4HRH3ALOX15 | |
| SCHEMBL603956 | 0.76 | HRH4 (0.77) | HRH4HRH3PARP1ALOX15 | |
| SCHEMBL602132 | 0.74 | HRH4 (1.00) | HRH4HRH3ALOX15 | |
| SCHEMBL602036 | 0.72 | HRH4 (0.90) | HRH4HRH3ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068211-A1 | TRICYCLIC INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-24 | — | — | WO | disclosed |