Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 1.00 |
| ▸ | HTR1B | P28222 | 19/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR1F | P30939 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8473270 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8472029 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8470232 | 0.91 | HTR1D (0.85) | HTR1DHTR1B | |
| SCHEMBL8524187 | 0.91 | HTR1D (0.85) | HTR1DHTR1B | |
| SCHEMBL8524184 | 0.91 | HTR1D (0.85) | HTR1DHTR1B | |
| SCHEMBL8471754 | 0.90 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8474241 | 0.90 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8470565 | 0.87 | HTR1D (0.77) | HTR1DHTR1B | |
| SCHEMBL8470562 | 0.87 | HTR1D (0.77) | HTR1DHTR1B | |
| SCHEMBL8470223 | 0.87 | HTR1D (0.77) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977116-A | Piperazine, piperidine and tetrahydropyridine derivatives | MERCK SHARP & DOHME LTD. (GB) | 1999-11-02 | — | — | US | disclosed |